Chronic Multisymptom Illness: VA/DoD Clinical Practice Guideline for the Management of Chronic Multisymptom Illness (2021)

This guideline summary outlines recommendations for the management of chronic multisymptom illness (CMI). CMI is characterized by multiple, persistent symptoms present or frequently recurring for more than six months, across more than one body system, and severe enough to interfere with daily functioning. Symptoms include fatigue, headache, arthralgias, myalgias, concentration and attention problems, and gastrointestinal disorders.